THE NEUROBEHAVIORAL IMPLICATIONS OF THE BRAIN AND MICROBIOTA INTERACTION


Application of Population Pharmacokinetic Analysis to Characterize CYP2C19 Mediated Metabolic Mechanism of Voriconazole and Support Dose Optimization

Purpose: The aims of this study were to establish a joint population pharmacokinetic model for voriconazole and its N-oxide metabolite in immunocompromised patients, to determine the extent to which the CYP2C19 genetic polymorphisms influenced the pharmacokinetic Control Board parameters, and to evaluate and optimize the dosing regimens using a sim

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Escalator Foundation Bolt Loosening Fault Recognition Based on Empirical Wavelet Transform and Multi-Scale Gray-Gradient Co-Occurrence Matrix

An escalator is an essential large-scale public transport equipment; once it fails, this inevitably affects the operation of the escalator and even leads to safety concerns, or perhaps accidents.As an important structural part of the escalator, the foundation of the main engine can cause the operation of the escalator to become abnormal when its fi

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